Benign prostatic hyperplasia (BPH) is one of the most common disease conditions in older men. An estimated 50% of men have histological BPH by age 50. The mechanisms of BPH pathogenesis is not well-understood. Our goal is to define the molecular and cellular mechanisms underlining BPH development and progression, particularly the role of inflammation.

Core Resources

To achieve our goals, we have developed an Administrative Core which includes an Educational Enrichment Program and a Tissue Resource and Morphology Core (TRMC). Read More »


To achieve the overall scientific goal of our O’Brien Center, we propose 3 research projects to characterize molecular and cellular alterations associated with BPH pathogenesis using cultured cells, animal models, and/or human BPH specimens.


To achieve our overall scientific goals we have protocols.